Susumu Muto Selected Research

I-kappa B Kinase

1/2009	Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation.
1/2009	Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.
3/2008	Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells.
2/2008	Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils.
5/2006	A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice.
1/2006	A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition.
10/2004	A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.

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Susumu Muto Research Topics

Disease

11	Inflammation (Inflammations) 07/2013 - 05/2006
5	Neoplasms (Cancer) 01/2012 - 01/2006
3	Myocardial Ischemia (Ischemic Heart Diseases) 03/2011 - 12/2008
3	Thrombosis (Thrombus) 02/2011 - 07/2008
2	Arthritis (Polyarthritis) 03/2011 - 08/2005
2	Asthma (Bronchial Asthma) 03/2011 - 01/2009
2	Myocarditis (Carditis) 02/2011 - 11/2008
2	Fibrosis (Cirrhosis) 02/2011 - 01/2007
2	Ventricular Remodeling 01/2011 - 01/2007
2	Reperfusion Injury 01/2011 - 07/2004
2	Carcinogenesis 01/2009 - 01/2006
2	Infarction (Infarctions) 01/2007 - 07/2004
2	Body Weight (Weight, Body) 05/2006 - 10/2004
1	Pulmonary Arterial Hypertension 07/2013
1	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 01/2012
1	Cardiovascular Diseases (Cardiovascular Disease) 02/2011
1	Vascular Remodeling 02/2011
1	Hypertension (High Blood Pressure) 02/2011
1	Arterial Occlusive Diseases (Arterial Occlusive Disease) 01/2011
1	Respiratory Hypersensitivity 01/2009
1	Colitis-Associated Neoplasms 01/2009
1	Colitis 01/2009
1	Hypersensitivity (Allergy) 01/2009
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2009
1	Heart Failure 12/2008
1	Neointima 07/2008
1	Pancreatic Neoplasms (Pancreatic Cancer) 03/2008
1	Gastritis 02/2008
1	Dermatitis 04/2007
1	Pheochromocytoma 04/2007
1	Atopic Dermatitis (Atopic Eczema) 04/2007
1	Myocardial Infarction 01/2007
1	Hyperplasia 11/2006
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/2006
1	Pneumonia (Pneumonitis) 05/2006
1	Leukemia 01/2006
1	Breast Neoplasms (Breast Cancer) 01/2006
1	Lymphoma (Lymphomas) 01/2006
1	Experimental Arthritis 08/2005
1	Rheumatoid Arthritis 08/2005
1	Systemic Mastocytosis 03/2005
1	Obesity 10/2004
1	Insulin Resistance 10/2004

Drug/Important Bio-Agent (IBA)

13	NF-kappa B (NF-kB)IBA 07/2013 - 07/2004
10	N- (3,5- bis(trifluoromethyl)phenyl)- 5- chloro- 2- hydroxybenzamideIBA 07/2013 - 07/2004
7	I-kappa B KinaseIBA 01/2009 - 10/2004
5	Plasminogen Activator Inhibitor 1IBA 02/2011 - 07/2008
4	Phosphotransferases (Kinase)IBA 01/2012 - 03/2008
4	CytokinesIBA 02/2011 - 07/2004
3	Plasminogen Activators (Plasminogen Activator)IBA 02/2011 - 11/2008
2	Proteins (Proteins, Gene)FDA Link 02/2011 - 02/2011
2	Matrix Metalloproteinases (MMPs)IBA 01/2011 - 12/2008
2	N- (2,5- bis(trifluoromethyl)phenyl)- 5- bromo- 2- hydroxybenzamideIBA 12/2008 - 08/2005
1	AldosteroneIBA 02/2011
1	Fibrinogen (Factor I)FDA Link 02/2011
1	OsteopontinIBA 02/2011
1	Collagen Type I (Type I Collagen)IBA 02/2011
1	Plasminogen InactivatorsIBA 01/2011
1	Fibrinolysin FDA Link 01/2011
1	AzoxymethaneIBA 01/2009
1	Peptides (Polypeptides)IBA 01/2009
1	benzamideIBA 01/2009
1	Transcription Factors (Transcription Factor)IBA 01/2009
1	Dextran SulfateIBA 01/2009
1	ChemokinesIBA 01/2009
1	Anti-Allergic Agents (Antiallergic Agents)IBA 01/2009
1	3- (3,4- dichlorobenzyl)- 5- (3,4,5- trihydroxybenzylidene)thiazolidine- 2,4- dioneIBA 07/2008
1	AgarIBA 03/2008
1	Clodronic Acid (Clodronate)IBA 02/2008
1	Tacrolimus (Prograf)FDA LinkGeneric 04/2007
1	Immunoglobulin E (IgE)IBA 04/2007
1	Ointments (Pastes)IBA 04/2007
1	Nerve Growth Factor (NGF)IBA 04/2007
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2007
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2007
1	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2007
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2007
1	HX 630IBA 11/2006
1	Bleomycin (Blenoxane)FDA LinkGeneric 05/2006
1	Collagen Type II (Type II Collagen)IBA 08/2005
1	Insulin (Novolin)FDA Link 10/2004
1	AdiponectinIBA 10/2004
1	NF-KappaB Inhibitor alphaIBA 07/2004

Therapy/Procedure

1	Heart Transplantation (Grafting, Heart) 01/2011
1	Sutures (Suture) 01/2011
1	Therapeutics 03/2008
1	Ligation 01/2007